Dendrimers as Antimicrobial Agents in the Central Nervous System Infections. A Review

Abstract Bacterial meningitis is a serious infection of the central nervous system that affects people all over world. Streptococcus pneumoniae and Neisseria meningitidis are most common pathogens causing meningeal inflammation in Europe. Treatment with standard antibiotics becoming ineffective, not only due to their inability cross blood-brain barrier, but also rising antibiotic resistance. As result, novel therapeutics combat required. A promising solution could be therapeutic nanomolecules, such as dendrimers, some which have antimicrobial properties chemical structure. Additionally, they may decorated suitable homing peptides construct nano-drug delivery systems, can effectively barrier. To synthesize safe dendrimeric it necessary select best dendrimer candidates activity understand pharmacosafety, pharmacokinetics dynamics. This review provides brief overview dendrimers been studied relation barrier existing antibiotics.